Description

4'-Methoxy-3'-(trifluoromethyl)acetophenone is a high-purity, versatile aromatic ketone building block featuring a methoxy and a trifluoromethyl group on the phenyl ring. This unique structure makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) drugs and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the trifluoromethyl group contributes to efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials for displays and lighting.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, Friedel-Crafts acylations, and as a precursor for heterocyclic compounds in academic and industrial research.
• Fine Chemical Production: Integral to manufacturing dyes, pigments, and other performance chemicals requiring specific aromatic substitution patterns.

Basic Information

Product Name	4'-Methoxy-3'-(Trifluoromethyl)Acetophenone
CAS No.	149105-10-2
Molecular Formula	C10H9F3O2
Molecular Weight	218.17 g/mol
Synonyms	1-[4-Methoxy-3-(trifluoromethyl)phenyl]ethanone; 3'-Trifluoromethyl-4'-methoxyacetophenone; 4-Methoxy-3-(trifluoromethyl)acetophenone; 1-(4-Methoxy-3-(trifluoromethyl)phenyl)ethan-1-one; 4-Methoxy-α,α,α-trifluoro-m-acetophenone; 3-(Trifluoromethyl)-4-methoxyacetophenone; 4'-Methoxy-3'-trifluoromethylacetophenone
EINECS	Contact for details

Quality Control

Our 4'-Methoxy-3'-(trifluoromethyl)acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.