Description

Difluoroacetaldehyde Ethyl Hemiacetal is a versatile fluorinated building block and protected form of difluoroacetaldehyde, a key synthon in modern organic synthesis. This compound is of significant value for introducing the difluoromethylene (CF2) group into target molecules, a modification that can dramatically alter physicochemical and biological properties. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, particularly protease inhibitors and kinase inhibitors where the CF2 group mimics a carbonyl or improves metabolic stability.
• Agrochemical Synthesis: Used to incorporate fluorine into herbicides, fungicides, and pesticides to enhance their activity, selectivity, and environmental profile.
• Material Science Research: Serves as a monomer or modifier in the development of specialty fluorinated polymers with unique surface properties, chemical resistance, or optical characteristics.
• Organic Synthesis Building Block: Employed in nucleophilic addition reactions, Grignard reactions, and reductive aminations to construct complex, fluorinated molecular architectures.
• Fluorine Chemistry Research: An essential reagent for academic and industrial labs exploring new methodologies for C-F bond formation and the synthesis of fluorinated heterocycles.

Basic Information

Product Name	Difluoroacetaldehyde Ethyl Hemiacetal
CAS No.	148992-43-2
Molecular Formula	C4H8F2O2
Molecular Weight	126.10 g/mol
Synonyms	1-Ethoxy-2,2-difluoroethanol; Ethyl 2,2-Difluoro-1-hydroxyethyl Ether; 2,2-Difluoro-1-ethoxyethanol; 1,1-Difluoro-2-ethoxyethanol; DFEA Hemiacetal; Difluoroacetaldehyde Ethyl Hemiacetal; (2,2-Difluoroethoxy)ethanol; Ethyl Difluoro(hydroxy)ethyl Ether
EINECS	Contact for details

Quality Control

Our Difluoroacetaldehyde Ethyl Hemiacetal is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing including GC, NMR, and HPLC to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting key parameters such as assay and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, keep containers tightly sealed when not in use and away from heat and open flame. Incompatible with strong bases and fluorinating agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.