Description

(R)-3,3,3-Trifluoropropane-1,2-Diol is a high-value chiral fluorinated building block, essential for introducing the trifluoromethyl group with defined stereochemistry into complex molecules. Its unique structure provides enhanced metabolic stability and lipophilicity, making it a critical intermediate in advanced pharmaceutical and agrochemical research. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a fluorinated component in the synthesis of specialty chemicals for electronic displays and organic light-emitting diodes (OLEDs).
• Asymmetric Catalysis & Ligand Design: Employed as a precursor for chiral ligands and catalysts used in enantioselective synthesis.
• Proteolysis Targeting Chimera (PROTAC) Linkers: Utilized in the construction of bifunctional molecules for targeted protein degradation therapies.
• Fluorinated Polymer & Material Science: Acts as a monomer or modifier to impart unique surface properties, chemical resistance, and stability to advanced polymers and coatings.

Basic Information

Product Name	(R)-3,3,3-Trifluoropropane-1,2-Diol
CAS No.	148683-13-0
Molecular Formula	C3H5F3O2
Molecular Weight	130.07 g/mol
Synonyms	(R)-3,3,3-Trifluoro-1,2-propanediol; (R)-3,3,3-Trifluoropropylene Glycol; (R)-1,1,1-Trifluoropropane-2,3-diol; (2R)-3,3,3-Trifluoropropane-1,2-diol; (R)-TFPO; (R)-TFPG; (R)-Trifluoromethyl-1,2-ethanediol; (R)-α-Trifluoromethyl glycol
EINECS	Contact for details

Quality Control

Our (R)-3,3,3-Trifluoropropane-1,2-Diol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment. We support custom synthesis and can tailor specifications to meet specific project requirements under cGMP guidelines if needed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). To prevent degradation, containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening and moisture uptake should be minimized.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.