Description

Cyclopropanecarboxaldehyde, 1-(Hydroxymethyl)-2-(1-Propenyl)-, [1R-[1Alpha,2Alpha(E)]]- (9Ci) is a chiral, functionalized cyclopropane derivative that serves as a sophisticated building block in advanced organic synthesis. Its unique structure, featuring both aldehyde and hydroxymethyl groups on a strained cyclopropane ring with a defined stereochemistry, makes it a valuable precursor for constructing complex molecular architectures. This high-purity intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in areas requiring complex, three-dimensional molecular scaffolds.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides where the cyclopropane moiety can impart specific biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the multistep synthesis of specialty chemicals, flavors, and fragrances requiring high stereochemical purity.
• Academic and Industrial R&D: A valuable compound for methodological studies in organic chemistry, exploring new cyclopropanation and ring-opening reactions.
• Material Science Precursor: Potential use in synthesizing monomers or additives for advanced polymeric materials with specific properties.

Basic Information

Item	Details
Product Name	Cyclopropanecarboxaldehyde, 1-(Hydroxymethyl)-2-(1-Propenyl)-, [1R-[1Alpha,2Alpha(E)]]- (9Ci)
CAS No.	148164-45-8
Molecular Formula	C8H12O2
Molecular Weight	140.18 g/mol
Synonyms	(1R,2R)-2-[(E)-Prop-1-en-1-yl]-1-(hydroxymethyl)cyclopropane-1-carbaldehyde; (1R,2R)-2-[(1E)-1-Propenyl]-1-(hydroxymethyl)cyclopropanecarboxaldehyde; [1R-[1α,2α(E)]]-1-(Hydroxymethyl)-2-(1-propenyl)cyclopropanecarboxaldehyde; Chiral Cyclopropane Aldehyde Derivative; Functionalized Cyclopropane Building Block
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, essential for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, chiral analysis, and NMR spectroscopy to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.