Description

4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine and difluoromethoxy substituents, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs for enhanced metabolic stability, bioavailability, and receptor binding.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve efficacy and environmental profile.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials due to its halogenated and fluorinated aromatic core.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create more complex biaryl and conjugated systems.
• Fluorine Chemistry Studies: Employed in academic and industrial R&D to study the effects of fluorine and difluoromethoxy substitution on chemical reactivity and physical properties.

Basic Information

Product Name	4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene
CAS No.	147992-27-6
Molecular Formula	C7H4BrF3O
Molecular Weight	241.01 g/mol
Synonyms	1-Bromo-4-(difluoromethoxy)-2-fluorobenzene; 2-Fluoro-4-bromo-1-(difluoromethoxy)benzene; 4-Bromo-2-fluoro-1-(difluoromethoxy)benzene; Benzene, 4-bromo-1-(difluoromethoxy)-2-fluoro-; 2-Fluoro-4-bromophenyl difluoromethyl ether
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Difluoromethoxy-2-Fluoro-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging during storage and handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.