Description

Epi-Triptolide CAS NO 147852-78-6 is a specific stereoisomer of the bioactive diterpenoid triepoxide, triptolide. This compound is of significant interest in advanced pharmaceutical research and development due to its distinct biological profile compared to its parent molecule. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutic agents, particularly for investigating structure-activity relationships and developing targeted therapies.

Application

• Pharmaceutical R&D Intermediate: Serves as a key chiral building block or reference standard in the synthesis and development of novel anti-inflammatory and immunosuppressive drug candidates.
• Biochemical Research: Used as a precise molecular tool to study cellular signaling pathways, apoptosis mechanisms, and the modulation of transcription factors like NF-κB in laboratory settings.
• Reference Standard: Employed in analytical laboratories for method development, validation, and quality control of related pharmaceutical compounds using techniques like HPLC and LC-MS.
• Preclinical Studies: Utilized in in vitro and in vivo studies to evaluate the efficacy, pharmacokinetics, and toxicity profile of triptolide analogs.

Basic Information

Product Name	Epi-Triptolide
CAS No.	147852-78-6
Molecular Formula	C20H24O6
Molecular Weight	360.40 g/mol
Synonyms	(5R,5aR,6aS,7S,8S,9R,9aR,10aR)-9,10,14-Trihydroxy-4b-methyl-3,6a,9a-trimethylenedioxy-5,5a,6,6a,7,8,9,9a,10,10a-decahydro-4bH-naphtho[2',3':3,4]cyclopenta[1,2-d][1,3]dioxol-8-yl acetate; Triptolide, epi-; Epitriptolide; (5R)-Triptolide; 14-Epitriptolide; PG490 epimer
EINECS	Contact for details

Quality Control

Our Epi-Triptolide is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your records and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.