Description

13,14-Epoxide-9,11,12-Trihydroxytriptolide is a highly functionalized diterpenoid triepoxide derivative of triptolide, a compound of significant interest in medicinal chemistry research. This molecule matters for its role as a key synthetic intermediate and a pharmacologically active scaffold, particularly in the study of anti-inflammatory and immunosuppressive agents. Pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers specializing in novel active pharmaceutical ingredients (APIs) are the primary users of this advanced chemical building block.

Application

• Pharmaceutical Research & Development: Serves as a critical intermediate in the synthesis and structural optimization of novel triptolide analogs for therapeutic applications.
• Medicinal Chemistry Studies: Used to investigate structure-activity relationships (SAR) to understand the impact of the epoxide and hydroxyl groups on biological activity and selectivity.
• Preclinical Bioactivity Screening: Employed in in vitro and in vivo studies targeting autoimmune diseases, inflammation, and certain oncology pathways.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in laboratories studying triptolide-related compounds.
• Fine Chemical Synthesis: Utilized as a sophisticated starting material or building block for the multi-step synthesis of complex natural product derivatives.

Basic Information

Product Name	13,14-Epoxide-9,11,12-Trihydroxytriptolide
CAS No.	147809-20-9
Molecular Formula	C20H24O7
Molecular Weight	376.40 g/mol
Synonyms	(5R,5aR,6R,6aS,7S,8S,9R,9aS,9bS)-6-(Hydroxymethyl)-2,3,5a,6,6a,7,8,9,9a,9b-decahydro-5,8,9-trihydroxy-5a-methyl-3-methylene-2-oxonaphtho[1,2-c]furan-7-yl oxirane-2-carboxylate; 9,11,12-Trihydroxy-13,14-epoxytriptolide; Triptolide derivative, 13,14-epoxy-9,11,12-trihydroxy-; 13,14-Epoxytriptolide triol
EINECS	Contact for details

Quality Control

Our 13,14-Epoxide-9,11,12-Trihydroxytriptolide is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere or in a desiccated environment at a controlled room temperature (15-25°C). For long-term storage, consider temperatures of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.