Description

Luffariolide F is a naturally occurring sesquiterpene lactone isolated from plants of the genus *Luffa*, exhibiting notable bioactivity in pharmacological research. It serves as a high-value reference standard and biochemical probe for studies targeting inflammation pathways, NF-κB signaling modulation, and anticancer mechanism elucidation. Research institutions, pharmaceutical R&D labs, and contract research organizations (CROs) rely on rigorously characterized Luffariolide F CAS NO 147663-78-3 for assay development, target validation, and structure–activity relationship (SAR) analysis.

Application

• Pharmacological reference standard for HPLC and LC-MS quantification in natural product bioanalysis
• Lead compound in anticancer drug discovery programs targeting apoptosis induction and cell cycle arrest
• Tool molecule for mechanistic studies of NF-κB and MAPK pathway inhibition in vitro
• Active ingredient in preclinical evaluation of anti-inflammatory and immunomodulatory effects
• Calibration standard for stability-indicating analytical methods in botanical extract quality control
• Substrate or inhibitor in cytochrome P450 (CYP) enzyme interaction studies
• Chemical probe for investigating sesquiterpene lactone–protein adduct formation and thiol reactivity
• Key intermediate in synthetic biology and semi-synthetic derivatization efforts to enhance solubility or potency

Basic Information

Product Name	Luffariolide F
CAS No.	147663-78-3
Molecular Formula	C15H18O4
Molecular Weight	262.30 g/mol
Synonyms	Luffariolide F; (3R,4R,5S,6R,7S,10R)-3,4-Dihydroxy-5,10-dimethyl-7-(2-oxopropyl)-2-oxabicyclo[2.2.2]oct-5-en-6-yl acetate; NSC 726597; Luffariolide-F; Luffariolide F (natural); 147663-78-3; Luffariolide F, ≥98% (HPLC); Luffariolide F (Luffa cylindrica)
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch of Luffariolide F is verified for identity (IR, HPLC, NMR), purity (≥98.0% by HPLC), residual solvents (GC), heavy metals (ICP-MS), and microbial limits (where applicable). Testing adheres to USP & EP guidelines for reference standards, and manufacturing follows ISO 9001 and GMP-compliant practices.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (nitrogen or argon) to prevent degradation. Keep away from heat, moisture, and strong oxidizing agents. Handle in a well-ventilated area using appropriate personal protective equipment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Odor	Characteristic, mild
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	≤2.0% total impurities
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals (as Pb)	≤10 ppm
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.