Description

{[2-(Trifluoromethyl)Phenyl]Methyl}Phosphonic Acid is a specialized organophosphorus compound featuring a trifluoromethylphenyl group, making it a valuable building block for advanced chemical synthesis. Its unique structure provides a synergistic combination of phosphonic acid functionality and fluorine substitution, which is critical for modifying the physicochemical properties of target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in materials science for creating functional surfaces and ligands.

Application

• Pharmaceutical Intermediate: A key synthon in the development of protease inhibitors, bone-targeting drugs, and other bioactive molecules where the phosphonic acid group acts as a bioisostere for phosphate or carboxylate.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, plant growth regulators, and fungicides, leveraging the metabolic stability imparted by the fluorine atoms.
• Ligand & Catalyst Preparation: Serves as a precursor for chelating ligands in coordination chemistry and catalysis, particularly useful in asymmetric synthesis and metal-organic frameworks (MOFs).
• Surface Modification Agent: Employed to functionalize metal oxides (e.g., titanium, aluminum) and other surfaces to create self-assembled monolayers (SAMs) with specific wetting, adhesion, or corrosion-resistant properties.
• Flame Retardant Additive: Investigated as a component in flame-retardant formulations for polymers and textiles, where phosphorus contributes to char formation.
• Chemical Research & Development: A versatile building block in organic and medicinal chemistry for constructing complex molecular architectures.

Basic Information

Product Name	{[2-(Trifluoromethyl)Phenyl]Methyl}Phosphonic Acid
CAS No.	146780-16-7
Molecular Formula	C8H8F3O3P
Molecular Weight	240.12 g/mol
Synonyms	(2-(Trifluoromethyl)benzyl)phosphonic acid; [2-(Trifluoromethyl)phenyl]methylphosphonic acid; α-(Trifluoromethyl)benzylphosphonic acid; Phosphonic acid, P-[[2-(trifluoromethyl)phenyl]methyl]-; (2-Trifluoromethylbenzyl)phosphonic acid; (α-Trifluoromethylbenzyl)phosphonic acid; 2-(Trifluoromethyl)benzylphosphonic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. Standard quality parameters include purity (Assay), identity confirmation, and control of key impurities. Certificates of Analysis (COA) detailing all test results are available upon request. We adhere to cGMP principles for manufacturing and can support development projects requiring material for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.