Description

4-(Trifluoromethyl)Phenylmethylphosphonic Acid is a high-purity organophosphorus compound characterized by its unique phenylmethylphosphonic acid core substituted with a trifluoromethyl group. This structure makes it a valuable key intermediate and building block in advanced chemical synthesis, particularly where the introduction of fluorine and phosphonic acid functionalities is required. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, especially protease inhibitors and other biologically active molecules containing phosphonate groups.
• Agrochemical Synthesis: Used as a key building block for developing advanced herbicides, pesticides, and plant growth regulators that benefit from the stability imparted by the fluorine substituents.
• Ligand and Catalyst Preparation: Employed in the preparation of specialized phosphonic acid-based ligands for metal catalysis and coordination chemistry.
• Material Science Research: Acts as a monomer or surface-modifying agent in the development of fluorinated polymers, coatings, and advanced functional materials.
• Chemical Synthesis Building Block: Provides a versatile scaffold for organic synthesis, enabling the introduction of both phosphonic acid and trifluoromethyl motifs into more complex architectures.

Basic Information

Product Name	4-(Trifluoromethyl)Phenylmethylphosphonic Acid
CAS No.	146780-15-6
Molecular Formula	C8H8F3O3P
Molecular Weight	240.12 g/mol
Synonyms	[(4-(Trifluoromethyl)phenyl)methyl]phosphonic acid; (4-Trifluoromethylbenzyl)phosphonic acid; α-(Trifluoromethyl)benzylphosphonic acid; 4-(Trifluoromethyl)benzylphosphonic acid; Phenylmethylphosphonic acid, 4-(trifluoromethyl)-; Phosphonic acid, P-[(4-(trifluoromethyl)phenyl)methyl]-
EINECS	Contact for details

Quality Control

Our production of 4-(Trifluoromethyl)Phenylmethylphosphonic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and titration, to ensure high purity and consistent chemical identity. A detailed Certificate of Analysis (COA) providing batch-specific results is supplied with each shipment to guarantee traceability and compliance with your research or manufacturing specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.