Description

Benzene, 1-(2,2-Dimethyl-1-Methylenepropyl)-3-(Trifluoromethyl)- is a specialized fluorinated aromatic compound characterized by its unique neopentyl and trifluoromethyl substituents. This structural motif makes it a valuable high-purity intermediate for advanced chemical synthesis, particularly in sectors demanding precise molecular architecture. It is primarily utilized by pharmaceutical, agrochemical, and advanced materials research and development teams for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group is a critical pharmacophore for activity.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), contributing to improved performance and stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific properties such as chemical resistance, low surface energy, or altered refractive index.
• Organic Synthesis & Catalysis: Employed in academic and industrial research as a sophisticated reagent for constructing complex organic frameworks and in catalyst ligand design.
• Fluorine Chemistry Research: A valuable compound for studying structure-activity relationships and developing new fluorination methodologies.

Basic Information

Item	Details
Product Name	Benzene, 1-(2,2-Dimethyl-1-Methylenepropyl)-3-(Trifluoromethyl)-
CAS No.	146558-45-4
Molecular Formula	C13H15F3
Molecular Weight	228.26 g/mol
Synonyms	3-(Trifluoromethyl)-α-(2,2-dimethylpropylidene)benzenemethane; 1-(2,2-Dimethyl-1-methylenepropyl)-3-(trifluoromethyl)benzene; 3-(Trifluoromethyl)benzylidene neopentane; (3-Trifluoromethylphenyl)neopentylidene methane; α-Neopentylidene-3-(trifluoromethyl)toluene; Neopentylidene(3-trifluoromethylphenyl)methane
EINECS	Contact for details

Quality Control

Our Benzene, 1-(2,2-Dimethyl-1-Methylenepropyl)-3-(Trifluoromethyl)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical data are provided with every shipment. We support compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.