Description

1-Bromo-4-Chloro-2-Fluoro-5-Methoxy-Benzene is a high-purity, multi-substituted benzene derivative serving as a critical building block in advanced organic synthesis. Its unique halogen and methoxy substitution pattern makes it an indispensable intermediate for creating complex molecules with tailored properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring specific halogenated aromatic cores.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the fluorine and chlorine atoms enhance biological activity.
• Liquid Crystal & OLED Materials: Serves as a building block for creating advanced electronic materials used in displays and lighting, leveraging its stable, substituted benzene structure.
• Organic Ligand Preparation: Employed in the development of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: A versatile scaffold for medicinal chemistry and structure-activity relationship (SAR) studies in academic and industrial labs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules under cGMP or research-grade conditions.

Basic Information

Product Name	1-Bromo-4-Chloro-2-Fluoro-5-Methoxy-Benzene
CAS No.	146447-18-9
Molecular Formula	C7H5BrClFO
Molecular Weight	239.47 g/mol
Synonyms	4-Bromo-1-Chloro-2-Fluoro-5-Methoxybenzene; 2-Fluoro-5-Methoxy-1-Bromo-4-Chlorobenzene; 5-Methoxy-2-fluoro-1-bromo-4-chlorobenzene; Benzene, 1-bromo-4-chloro-2-fluoro-5-methoxy-; 1-Bromo-4-chloro-2-fluoro-5-methoxybenzene
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-4-Chloro-2-Fluoro-5-Methoxy-Benzene is produced and tested under a strict quality management system. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.