Description

2,4,6-Trifluoro-D-Phenylalanine is a non-natural, fluorinated derivative of the essential amino acid phenylalanine. This compound is of significant interest due to its role as a key chiral building block in the synthesis of complex pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based drugs, enzyme inhibitors, and advanced materials where the introduction of fluorine atoms can dramatically alter metabolic stability, lipophilicity, and binding affinity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate fluorinated aromatic side chains, modifying the biological activity and physicochemical properties of therapeutic peptides.
• Proteomics & Biochemical Research: Serves as a tool compound in enzyme inhibition studies and metabolic pathway analysis, leveraging fluorine as a spectroscopic probe (¹⁹F NMR).
• Material Science: Potential precursor for advanced organic materials and liquid crystals, where fluorination enhances thermal stability and electronic properties.
• Agrochemical Research: Employed in the design of novel herbicides and pesticides, where the trifluoromethylphenyl group is a common bioactive motif.

Basic Information

Product Name	2,4,6-Trifluoro-D-Phenylalanine
CAS No.	146277-48-7
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	D-2,4,6-Trifluorophenylalanine; (R)-2-Amino-3-(2,4,6-trifluorophenyl)propanoic acid; (R)-2,4,6-Trifluorophenylalanine; 2,4,6-Trifluoro-D-phenylalanine; D-α-Amino-2,4,6-trifluorohydrocinnamic acid; (2R)-2-Azaniumyl-3-(2,4,6-trifluorophenyl)propanoate; F3Phe-OH (D-isomer)
EINECS	Contact for details

Quality Control

Our 2,4,6-Trifluoro-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.