Description

(4R,5R)-4,5-Bis(Aminomethyl)-2-Isopropyl-1,3-Dioxolane is a high-purity chiral dioxolane derivative featuring two primary amino groups, making it a versatile and valuable building block in advanced organic synthesis. This compound is critical for the development of complex molecules where stereochemical control and functional group density are paramount. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as chiral ligand synthesis, catalyst development, and the construction of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in antiviral, antibacterial, and central nervous system (CNS) therapeutic areas.
• Chiral Ligand & Catalyst Precursor: Used to develop novel asymmetric catalysts and ligands for enantioselective synthesis in fine chemical production.
• Agrochemical Synthesis: Serves as a building block for creating chiral active ingredients in herbicides, fungicides, and insecticides.
• Polymer Modification: The primary amine groups can be used to introduce functionality into polymers, creating materials with specific adhesive, coating, or biocompatible properties.
• Crosslinking Agent: Functions as a crosslinker in epoxy resin systems and other thermosetting polymers, enhancing material strength and thermal stability.
• Chelating Agent Synthesis: A precursor for synthesizing multidentate chelating agents used in metal ion sequestration and catalysis.

Basic Information

Product Name	(4R,5R)-4,5-Bis(Aminomethyl)-2-Isopropyl-1,3-Dioxolane
CAS No.	146092-05-9
Molecular Formula	C9H18N2O2
Molecular Weight	186.25 g/mol
Synonyms	(4R,5R)-2-Isopropyl-1,3-dioxolane-4,5-dimethanamine; (4R,5R)-4,5-Bis(aminomethyl)-2-(1-methylethyl)-1,3-dioxolane; (4R-cis)-4,5-Bis(aminomethyl)-2-isopropyl-1,3-dioxolane; (R,R)-2-Isopropyl-1,3-dioxolane-4,5-diyldimethanamine; Chiral Dioxolane Diamine; 2-Isopropyl-4,5-bis(aminomethyl)-1,3-dioxolane (R,R)-isomer
EINECS	Contact for details

Quality Control

Our (4R,5R)-4,5-Bis(Aminomethyl)-2-Isopropyl-1,3-Dioxolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including chiral purity verification by HPLC, to meet the stringent requirements of research and process development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.