Description

(S)-(+)-2-Phenyl-n-(Trifluoroacetyl)-Glycine Methyl Ester, 97 is a high-purity chiral building block and synthetic intermediate of significant value in advanced organic synthesis. This compound is specifically designed for applications requiring enantiomeric purity, serving as a key precursor in the development of pharmaceuticals and fine chemicals. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of peptidomimetics and enzyme inhibitors.
• Asymmetric Synthesis: Used as a starting material or reagent in asymmetric synthesis to introduce the (S)-2-phenylglycine moiety into target molecules with high stereoselectivity.
• Peptide Chemistry: Serves as a protected amino acid derivative for the solid-phase or solution-phase synthesis of modified peptides and peptide analogs.
• Agrochemical Research: Employed in the research and development of novel chiral herbicides, fungicides, and plant growth regulators.
• Catalyst & Ligand Development: Acts as a precursor for the synthesis of novel chiral ligands and organocatalysts used in enantioselective transformations.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and for exploring new synthetic pathways in both academic and industrial research laboratories.

Basic Information

Product Name	(S)-(+)-2-Phenyl-n-(Trifluoroacetyl)-Glycine Methyl Ester, 97
CAS No.	145513-97-9
Molecular Formula	C₁₂H₁₂F₃NO₃
Molecular Weight	275.22 g/mol
Synonyms	(S)-2-Phenyl-2-[(trifluoroacetyl)amino]acetic acid methyl ester; Methyl (S)-2-[(trifluoroacetyl)amino]-2-phenylacetate; (S)-N-Trifluoroacetylphenylglycine methyl ester; (S)-α-Phenyl-N-(trifluoroacetyl)glycine methyl ester; L-N-Trifluoroacetylphenylglycine methyl ester; (S)-(+)-N-TFA-Phenylglycine-OMe; (S)-Methyl 2-phenyl-2-(trifluoroacetamido)acetate; TFA-L-Phe-Gly-OMe (context-specific)
EINECS	Contact for details

Quality Control

Our (S)-(+)-2-Phenyl-n-(Trifluoroacetyl)-Glycine Methyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (e.e.) verification. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity (typically ≥97%), and impurity profiles. Our quality management system supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if frequent access is required. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% e.e.
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.