Description

2-Chloro-4-Methylphenylboronic Acid Pinacol Ester is a protected boronic acid derivative, a crucial intermediate in modern synthetic organic chemistry. Its primary value lies in its enhanced stability and handling properties compared to the free boronic acid, making it an essential reagent for high-value chemical synthesis. This compound is particularly needed by researchers and process chemists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key building block for creating biaryl and heterobiaryl structures, which are core motifs in many active pharmaceutical ingredients (APIs) and agrochemicals.
• Pharmaceutical Intermediate: Used in the synthesis of drug candidates targeting a wide range of therapeutic areas, where the chloromethylphenyl moiety is a valuable pharmacophore.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced herbicides, fungicides, and insecticides that require specific halogenated aromatic systems.
• Material Science Research: Employed in the creation of organic electronic materials, such as ligands for OLEDs or molecular components for organic semiconductors.
• Chemical Library Development: A valuable scaffold for medicinal chemistry and high-throughput screening libraries due to its derivatization potential.
• Catalyst and Ligand Preparation: Can be utilized to synthesize novel boron-containing ligands for transition metal catalysis.

Basic Information

Product Name	2-Chloro-4-Methylphenylboronic Acid Pinacol Ester
CAS No.	145349-62-8
Molecular Formula	C₁₃H₁₈BClO₂
Molecular Weight	252.54 g/mol
Synonyms	2-Chloro-4-methylbenzeneboronic acid pinacol ester; (2-Chloro-4-methylphenyl)boronic acid pinacol ester; 4-Chloro-2-methylbenzeneboronic acid pinacol ester; Pinacol (2-chloro-p-tolyl)boronate; B-(2-Chloro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Chloro-4-methylphenylboronic acid, pinacol ester; CAS 145349-62-8
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Methylphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.