Description

2'-Fluoro-5'-Hydroxyacetophenone is a fluorinated aromatic ketone derivative that serves as a versatile and high-value synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both a fluorine atom and a phenolic hydroxyl group, makes it a critical building block for constructing complex molecules with tailored properties. This compound is essential for research and development chemists and manufacturers in the pharmaceutical, agrochemical, and material science sectors seeking to incorporate fluorinated motifs into their target compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, oncology, and metabolic diseases where fluorine substitution is used to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and pesticides, leveraging the fluorine atom to enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Used in the development of fluorinated organic semiconductors and liquid crystal molecules for display technologies and electronic devices.
• Advanced Polymer Chemistry: Monomer or modifier for creating specialty polymers with enhanced thermal stability, chemical resistance, or specific optical properties.
• Chemical Research & Development: A valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and in organic methodology development for novel fluorination reactions.

Basic Information

Product Name	2'-Fluoro-5'-Hydroxyacetophenone
CAS No.	145300-04-5
Molecular Formula	C8H7FO2
Molecular Weight	154.14 g/mol
Synonyms	1-(2-Fluoro-5-hydroxyphenyl)ethanone; 2'-Fluoro-5'-hydroxyacetophenone; 2-Fluoro-5-hydroxyacetophenone; 1-Acetyl-2-fluoro-5-hydroxybenzene; 2-Fluoro-5-acetylphenol; 5-Acetyl-2-fluorophenol; Ethanone, 1-(2-fluoro-5-hydroxyphenyl)-
EINECS	Contact for details

Quality Control

Our 2'-Fluro-5'-Hydroxyacetophenone is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.