Description

2',4'-Difluoro-2-Hydroxyacetophenone is a specialized fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. This compound is valued for its unique molecular structure, which serves as a critical precursor in the development of complex, high-value chemical entities. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for applications in medicinal chemistry and active ingredient development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorophenol or related fluorinated motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides where the difluoro-hydroxyacetophenone scaffold imparts desired biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of advanced polymers and organic electronic materials due to its fluorinated aromatic structure.
• Chemical Research & Development: A versatile starting material for exploring new fluorination reactions and synthesizing complex heterocyclic compounds in academic and industrial R&D labs.

Basic Information

Product Name	2',4'-Difluoro-2-Hydroxyacetophenone
CAS No.	145240-42-2
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	1-(2,4-Difluorophenyl)-2-hydroxyethan-1-one; 2',4'-Difluoro-2-hydroxyacetophenone; 2-Hydroxy-2',4'-difluoroacetophenone; 2-Acetyl-3,5-difluorophenol; (2,4-Difluorophenyl)(hydroxy)methyl ketone; α-Hydroxy-2,4-difluoroacetophenone
EINECS	Contact for details

Quality Control

Our 2',4'-Difluoro-2-Hydroxyacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.