Description

(R)-3-Amino-4-Phenylbutyric Acid Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in the development of cardiovascular and neurological drugs. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in asymmetric synthesis.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of renin inhibitors, such as Aliskiren, and other cardiovascular therapeutics.
• Asymmetric Synthesis: Used as a starting material or precursor in the synthesis of complex, enantiomerically pure molecules for drug discovery programs.
• Peptidomimetics Research: Serves as a constrained γ-amino acid analog for constructing novel peptide-like structures in medicinal chemistry.
• Bioconjugation & Labeling: The amine and carboxylic acid functional groups allow for site-specific modification and linker attachment in bioconjugate chemistry.
• Chemical Biology Probes: Utilized in the development of enzyme inhibitors and receptor ligands for biochemical pathway studies.
• Custom Synthesis: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API manufacturing under cGMP conditions.

Basic Information

Product Name	(R)-3-Amino-4-Phenylbutyric Acid Hydrochloride
CAS No.	145149-50-4
Molecular Formula	C10H14ClNO2
Molecular Weight	215.68 g/mol
Synonyms	(R)-3-Amino-4-phenylbutanoic acid hydrochloride; (R)-3-Amino-4-phenylbutyric acid HCl; (3R)-3-Amino-4-phenylbutanoic acid hydrochloride; (R)-γ-Amino-β-phenylbutyric acid hydrochloride; (R)-APBA hydrochloride; (R)-3-Amino-4-phenylbutyrate hydrochloride; (R)-Homophenylalanine hydrochloride; (R)-HPA HCl
EINECS	Contact for details

Quality Control

Our (R)-3-Amino-4-Phenylbutyric Acid Hydrochloride is manufactured under strict quality systems. We provide material suitable for pharmaceutical R&D and advanced synthesis, with typical purity exceeding 98.0% (by HPLC). Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing chiral purity (enantiomeric excess), assay, and impurity profiles. Specifications can be aligned with customer requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.