Description

(10E)-10,11-Didehydro-11-Deoxy-6-o-Methylerythromycin CAS NO 144604-03-5 is a semi-synthetic derivative of the macrolide antibiotic erythromycin, specifically engineered to enhance stability and modify biological activity. This compound is of significant value in pharmaceutical research and development, serving as a key intermediate for synthesizing advanced macrolide antibiotics with improved pharmacokinetic profiles. It is primarily needed by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers focused on developing next-generation antibacterial agents and exploring novel therapeutic applications.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of advanced macrolide antibiotics, such as clarithromycin derivatives.
• Antibacterial Research: Used in R&D to study structure-activity relationships (SAR) and develop new compounds with enhanced efficacy against resistant bacterial strains.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in the multi-step synthesis of complex antibiotic APIs under Good Manufacturing Practice (GMP) conditions.
• Biochemical Studies: Employed in microbiological and pharmacological research to investigate mechanisms of action and bacterial ribosome inhibition.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical testing laboratories.
• Fine Chemical Production: Supplied to fine chemical manufacturers for custom synthesis projects and contract manufacturing.

Basic Information

Product Name	(10E)-10,11-Didehydro-11-Deoxy-6-o-Methylerythromycin
CAS No.	144604-03-5
Molecular Formula	C38H67NO12
Molecular Weight	729.94 g/mol
Synonyms	6-O-Methylerythromycin A 10,11-ene; 10,11-Anhydro-6-O-methylerythromycin A; 10,11-Didehydro-11-deoxy-6-O-methylerythromycin; 6-O-Methyl-10,11-anhydroerythromycin A; 10,11-Didehydro-11-deoxy-6-O-methylerythromycin A; (10E)-10,11-Didehydro-11-deoxy-6-O-methylerythromycin; Erythromycin, 10,11-didehydro-11-deoxy-6-O-methyl-, (10E)-
EINECS	Contact for details

Quality Control

Our (10E)-10,11-Didehydro-11-Deoxy-6-o-Methylerythromycin is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with high-grade pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development and commercial projects with material suitable for research use through to GMP-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single impurity ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.