Description

1,3-Difluoro-2-Methylpropan-2-Ol is a versatile fluorinated alcohol building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and a tertiary alcohol group, which are critical for modulating the physical, chemical, and biological properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for introducing fluorine into drug candidates to enhance metabolic stability, bioavailability, and membrane permeability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where fluorine substitution improves efficacy and environmental profile.
• Liquid Crystal & Electronic Materials: Serves as a precursor for fluorinated components in display technologies and dielectric fluids.
• Polymer Modification: Incorporated to create specialty fluoropolymers with unique surface properties, chemical resistance, and thermal stability.
• Organic Synthesis Building Block: Employed in nucleophilic substitution and coupling reactions to construct complex, fluorinated molecular architectures.
• Solvent & Reaction Medium: Its unique polarity can be utilized as a specialty solvent for specific chemical transformations.

Basic Information

Product Name	1,3-Difluoro-2-Methylpropan-2-Ol
CAS No.	144521-63-1
Molecular Formula	C4H8F2O
Molecular Weight	110.10 g/mol
Synonyms	1,3-Difluoro-2-methyl-2-propanol; 2-Methyl-1,3-difluoro-2-propanol; 2-(Difluoromethyl)-2-propanol; 1,3-Difluoro-tert-butanol; DFMP; 2-Methyl-2-(difluoromethyl)oxirane (precursor); Hexafluoroacetone hydrate (related derivative)
EINECS	Contact for details

Quality Control

Every batch of 1,3-Difluoro-2-Methylpropan-2-Ol is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, and custom specifications can be developed to support your project.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at room temperature (15-25°C). Due to its nature as a fluoride/strong alkali and highly volatile compound, ensure containers are kept tightly sealed in a dry environment away from incompatible materials. For long-term storage, consider using inert gas headspace.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.