Description

(E)-Ethylidenesuccinic Acid CAS NO 144368-21-8 is a high-purity, unsaturated dicarboxylic acid derivative that serves as a versatile building block in advanced organic synthesis. Its unique molecular structure, featuring a conjugated double bond, makes it a valuable intermediate for creating complex molecules with specific functional properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries seeking to develop novel active ingredients and performance materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in protease inhibitor and anti-inflammatory agent research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and plant growth regulators, leveraging its reactive double bond for functionalization.
• Polymer & Resin Modifier: Acts as a co-monomer or cross-linking agent to introduce carboxylic acid functionality and improve adhesion or solubility in specialty coatings and resins.
• Fine Chemical Production: Serves as a precursor for synthesizing complex esters, amides, and other derivatives used in flavors, fragrances, and electronic chemicals.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including Diels-Alder reactions and conjugate addition explorations.
• Chelating Agent Precursor: The basis for synthesizing novel chelating ligands for metal catalysis or sequestration applications.

Basic Information

Product Name	(E)-Ethylidenesuccinic Acid
CAS No.	144368-21-8
Molecular Formula	C6H8O4
Molecular Weight	144.13 g/mol
Synonyms	(E)-2-Butenedioic acid, 2-ethylidene-; trans-2-Ethylidenesuccinic acid; (E)-2-Ethylidenebutanedioic acid; Itaconic acid isomer; Methylenesuccinic acid derivative; 2-Ethylidene-2-butenedioic acid; (E)-1,2,3,6-Tetrahydrophthalic acid (tautomer reference)
EINECS	Contact for details

Quality Control

Our (E)-Ethylidenesuccinic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and reliability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of heat.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.