Description

Ethyl 4-Methyl-2-[3-(Trifluoromethyl)Phenyl]Thiazole-5-Carboxylate is a high-value, multi-functional heterocyclic building block and advanced pharmaceutical intermediate. Its core value lies in the unique trifluoromethylphenyl-thiazole scaffold, which is critical for imparting desirable biological activity, metabolic stability, and lipophilicity in active molecules. This compound is essential for R&D and production teams in the pharmaceutical, agrochemical, and advanced material sectors seeking to develop novel therapeutics and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in therapeutic areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a critical building block for developing next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiazole ring.
• Material Science Research: Used in the development of organic semiconductors, liquid crystals, and fluorescent dyes due to its electron-deficient aromatic system.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tag in the design of chemical probes and enzyme inhibitors for target validation studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring specialized fluorinated heterocycles.

Basic Information

Product Name	Ethyl 4-Methyl-2-[3-(Trifluoromethyl)Phenyl]Thiazole-5-Carboxylate
CAS No.	144061-14-3
Molecular Formula	C14H12F3NO2S
Molecular Weight	315.31 g/mol
Synonyms	Ethyl 4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate; 5-Thiazolecarboxylic acid, 4-methyl-2-[3-(trifluoromethyl)phenyl]-, ethyl ester; 2-(3-Trifluoromethylphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester; Ethyl 4-methyl-2-(3-trifluoromethylphenyl)thiazole-5-carboxylate; 144061-14-3; Ethyl 2-(3-(trifluoromethyl)phenyl)-4-methylthiazole-5-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 4-Methyl-2-[3-(Trifluoromethyl)Phenyl]Thiazole-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC, to ensure it meets the stringent requirements of our global clientele. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.