Description

(S)-tert-Butyl 4-Chloro-3-Hydroxybutanoate is a high-value chiral building block and pharmaceutical intermediate of significant importance in asymmetric synthesis. Its core value lies in the presence of three distinct functional groups—a protected hydroxyl, a chloro, and an ester—which allow for versatile and stereoselective transformations. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), particularly in the synthesis of statin drugs and other complex chiral molecules. Its defined stereochemistry ensures high purity and predictable reaction outcomes in critical synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of cholesterol-lowering statin drugs like Atorvastatin and Rosuvastatin.
• Asymmetric Synthesis: Used as a precursor for introducing chiral centers in complex organic molecules via nucleophilic substitution or reduction reactions.
• API Development: Serves as a critical building block in research and process development for new Active Pharmaceutical Ingredients (APIs).
• Fine Chemical Production: Employed in the manufacture of other high-purity, specialty fine chemicals and advanced intermediates.
• Chemical Research: Utilized in academic and industrial R&D for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	(S)-tert-Butyl 4-Chloro-3-Hydroxybutanoate
CAS No.	143839-39-8
Molecular Formula	C8H15ClO3
Molecular Weight	194.66 g/mol
Synonyms	(S)-(-)-tert-Butyl 4-chloro-3-hydroxybutyrate; (3S)-4-Chloro-3-hydroxybutyric acid tert-butyl ester; tert-Butyl (S)-(-)-4-chloro-3-hydroxybutanoate; (S)-4-Chloro-3-hydroxybutyric acid tert-butyl ester; (S)-Tert-butyl 4-chloro-3-hydroxybutyrate; (S)-TBCHB; (S)-HBCB-tBu
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 4-Chloro-3-Hydroxybutanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications for identity, assay, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.