Description

n-Cbz-D-Prolinal CAS NO 143393-11-7 is a high-purity, chiral protected amino aldehyde derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, particularly in pharmaceutical research and development. This compound is essential for scientists and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for peptide mimetics, protease inhibitors, and other bioactive compound synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly those targeting enzymatic pathways.
• Peptidomimetic Synthesis: Used to introduce the D-proline scaffold into peptide backbones to enhance metabolic stability and bioavailability.
• Protease Inhibitor Development: Serves as a precursor in the creation of inhibitors for various proteases, a significant class of therapeutic targets.
• Asymmetric Synthesis: Employed in stereocontrolled reactions to create complex chiral centers with high enantiomeric purity.
• Bioconjugation & Labeling: The aldehyde functionality allows for selective conjugation with amines, useful in probe and linker chemistry.
• Academic & Contract Research: A valuable reagent for research institutions and CROs exploring new synthetic methodologies and bioactive molecules.

Basic Information

Product Name	n-Cbz-D-Prolinal
CAS No.	143393-11-7
Molecular Formula	C₁₄H₁₇NO₄
Molecular Weight	263.29 g/mol
Synonyms	D-N-Carbobenzoxyprolinal; (R)-1-((Benzyloxy)carbonyl)pyrrolidine-2-carboxaldehyde; (R)-N-Cbz-Prolinal; (R)-2-Formyl-1-[(phenylmethoxy)carbonyl]pyrrolidine; N-[(Benzyloxy)carbonyl]-D-prolinal; N-Carbobenzyloxy-D-prolinal; Z-D-Prolinal; CBZ-D-Prolinal
EINECS	Contact for details

Quality Control

Every batch of n-Cbz-D-Prolinal is manufactured under strict quality management protocols. We employ advanced analytical techniques, including HPLC, NMR, and chiral analysis, to ensure identity, purity, and enantiomeric excess meet the stringent requirements of research and cGMP starting material applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.