Description

R-(+)-2-Trifluoromethyloxirane is a high-value, chiral epoxide building block characterized by its trifluoromethyl group. This compound matters for its role in introducing the metabolically stable and lipophilic trifluoromethyl moiety into target molecules, a key strategy in modern medicinal and agrochemical design. It is primarily needed by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for the synthesis of novel bioactive compounds and specialty polymers.

Application

• As a key chiral intermediate in the synthesis of pharmaceutical candidates, particularly those targeting central nervous system (CNS) disorders.
• For the preparation of agrochemicals, where the trifluoromethyl group enhances biological activity and environmental stability.
• In asymmetric synthesis to construct complex molecules with defined stereochemistry for drug discovery programs.
• As a monomer or precursor in the development of specialty fluorinated polymers with unique surface properties and chemical resistance.
• For ligand and catalyst development in organometallic chemistry and catalysis research.
• In material science research to create novel fluorinated coatings and electronic materials.

Basic Information

Product Name	R-(+)-2-Trifluoromethyloxirane
CAS No.	143142-90-9
Molecular Formula	C3H3F3O
Molecular Weight	112.05 g/mol
Synonyms	(R)-(+)-3,3,3-Trifluoropropylene oxide; (R)-2-(Trifluoromethyl)oxirane; (R)-3,3,3-Trifluoro-1,2-epoxypropane; (R)-Trifluoromethyloxirane; (R)-TMPO; (R)-TFPO; (+)-2-Trifluoromethyloxirane; (2R)-2-(Trifluoromethyl)oxirane
EINECS	Contact for details

Quality Control

Our R-(+)-2-Trifluoromethyloxirane is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity assessment by GC or HPLC, to ensure high enantiomeric excess (e.e.) and chemical purity suitable for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place, ideally at 2-8°C. Keep away from strong acids, bases, and oxidizing agents. Handle and open containers with appropriate precautions in a fume hood.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Enantiomeric Excess (Chiral GC/HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.