Description

Carbofos-2,3-14C is a radiolabeled analog of the organophosphate insecticide carbofos (malathion), specifically labeled with carbon-14 at the 2 and 3 positions of the succinate moiety. This compound is an essential tool for conducting advanced metabolism, environmental fate, and residue studies with high precision and traceability. It is primarily required by agrochemical R&D laboratories, environmental testing facilities, and contract research organizations (CROs) engaged in regulatory compliance and scientific research.

Application

• Metabolism and Pharmacokinetic Studies: Tracing the absorption, distribution, metabolism, and excretion (ADME) pathways of carbofos in target organisms and plants.
• Environmental Fate Research: Investigating the degradation, persistence, and movement (leaching, volatilization) of carbofos in soil and water systems.
• Residue Analysis: Serving as an internal standard or tracer in analytical methods (e.g., LC-MS) to quantify carbofos residues in food, feed, and environmental samples for regulatory submissions.
• Mode of Action Research: Studying the biochemical interactions and inhibition mechanisms of carbofos on target enzymes like acetylcholinesterase.
• Toxicology and Ecotoxicology: Enabling precise dosing and tracking in studies assessing the toxicological impact on non-target species and ecosystems.
• Biodegradation Studies: Monitoring the breakdown of carbofos by microbial communities in bioremediation research.

Basic Information

Product Name	Carbofos-2,3-14C
CAS No.	142702-36-1
Molecular Formula	C10H19O6PS2 * (14C labeled)
Molecular Weight	~330.4 g/mol (unlabeled)
Synonyms	Malathion-2,3-14C; S-1,2-Bis(ethoxycarbonyl)ethyl O,O-dimethyl phosphorodithioate-2,3-14C; Mercaptosuccinic acid diethyl ester, O,O-dimethyl phosphorodithioate-2,3-14C; Carbofos-14C; [14C]-Malathion; Radiolabeled Malathion; Diethyl (dimethoxyphosphinothioylthio)succinate-2,3-14C
EINECS	Contact for details

Quality Control

Every batch of Carbofos-2,3-14C is synthesized and purified under controlled conditions to ensure exceptional radiopurity and chemical purity. Quality is verified through comprehensive analytical techniques including HPLC with radiometric detection, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, specifying specific activity, radiochemical purity, chemical purity, and solvent information, ensuring compliance with the stringent requirements of research and regulatory studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in the original solvent as specified on the label. Solutions should be kept in sealed vials to prevent solvent evaporation and potential concentration changes. Follow all local and international regulations for the safe handling and storage of radioactive materials.

Specification

Item	Specification
Appearance	Clear solution
Specific Activity	50-60 mCi/mmol (Contact for specific batch data)
Radiochemical Purity (RCP)	≥ 97% (by HPLC)
Chemical Purity	≥ 95% (by HPLC)
Concentration	0.1 mCi/mL in toluene (or as specified)
Identification	HPLC co-elution with reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.