Description

4-(4-Carboxy-Butyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, multi-functional piperidine derivative that serves as a critical building block in advanced organic synthesis. This compound matters because it provides a protected carboxylic acid and a tert-butyloxycarbonyl (Boc) protected amine, offering orthogonal reactivity for the precise construction of complex molecules. Pharmaceutical researchers and fine chemical manufacturers need it for developing active pharmaceutical ingredients (APIs), peptidomimetics, and other specialized organic compounds where controlled functional group manipulation is essential.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic diseases.
• Peptide & Peptidomimetic Synthesis: Used to introduce the piperidine scaffold with protected functionalities, enabling the creation of conformationally constrained peptide analogs and protease inhibitors.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing sophisticated ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Agrochemical Research: Employed in the synthesis of novel active ingredients for crop protection, leveraging its structural complexity for bioactivity.
• Material Science Monomer: Can be utilized to create novel polymers and dendrimers with specific functional properties for advanced material applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	4-(4-Carboxy-Butyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	142638-91-3
Molecular Formula	C16H29NO4
Molecular Weight	299.41 g/mol
Synonyms	1-Boc-4-(4-carboxybutyl)piperidine; 4-(4-Carboxybutyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(4-carboxybutyl)piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(4-carboxybutyl)piperidine; 4-(4-Carboxybutyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; Piperidine-1-carboxylic acid, 4-(4-carboxybutyl)-, 1,1-dimethylethyl ester; Boc-4-(4-COOH-Bu)-piperidine
EINECS	Contact for details

Quality Control

Our 4-(4-Carboxy-Butyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications requiring high-purity intermediates, from early-stage R&D to cGMP manufacturing for pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere to maintain optimal purity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.