Description

n-Boc-4-Piperidineacetaldehyde CAS NO 142374-19-4 is a high-purity, protected aldehyde derivative of 4-piperidineacetaldehyde, serving as a critical chiral building block and versatile synthetic intermediate in advanced organic synthesis. Its primary value lies in enabling the efficient construction of complex nitrogen-containing heterocycles and pharmacophores, particularly for active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new therapeutic agents and specialty molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of piperidine-based drug candidates, including kinase inhibitors, receptor antagonists, and central nervous system (CNS) active compounds.
• Peptidomimetic Synthesis: Used to introduce aldehyde functionality for subsequent reductive amination or other ligation strategies in creating peptide analogs and macrocycles.
• Agrochemical Development: Building block for novel pesticides and herbicides that incorporate the piperidine scaffold for enhanced biological activity.
• Ligand and Catalyst Preparation: Intermediate for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the development of molecular probes and bioconjugates for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	n-Boc-4-Piperidineacetaldehyde
CAS No.	142374-19-4
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	1-Boc-4-Piperidineacetaldehyde; tert-Butyl 4-(2-oxoethyl)piperidine-1-carboxylate; 4-(2-Oxoethyl)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-piperidineacetaldehyde; N-Boc-4-(2-oxoethyl)piperidine; 4-(2-Oxoethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; N-Boc-piperidine-4-acetaldehyde
EINECS	Contact for details

Quality Control

Our n-Boc-4-Piperidineacetaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, well-ventilated place. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.