Description

1H-1,2,4-Triazole,5-[(1,1-Dimethylethyl)dimethylsilyl]-1-methyl-(9Ci) is a high-value, organosilicon-protected triazole derivative, primarily utilized as a sophisticated synthetic intermediate. Its core value lies in providing a sterically hindered, silylated nitrogen heterocycle that enables precise control in complex organic transformations, particularly in pharmaceutical and advanced material synthesis. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require advanced building blocks for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key protected synthon in the synthesis of novel triazole-containing drug candidates, including antifungal agents, kinase inhibitors, and other biologically active molecules.
• Agrochemical Synthesis: Used in the research and development of next-generation pesticides, herbicides, and fungicides where the triazole moiety is a critical pharmacophore.
• Ligand & Catalyst Preparation: Serves as a precursor for creating specialized N-heterocyclic carbene (NHC) ligands or other coordinating agents used in transition metal catalysis.
• Material Science Research: Employed in the development of advanced polymers, coatings, or silicon-based hybrid materials with tailored properties.
• Custom Synthesis & Process R&D: A valuable building block for contract research organizations (CROs) and fine chemical companies engaged in custom synthesis projects.

Basic Information

Product Name	1H-1,2,4-Triazole,5-[(1,1-Dimethylethyl)dimethylsilyl]-1-methyl-(9Ci)
CAS No.	142208-88-6
Molecular Formula	C9H19N3Si
Molecular Weight	197.36 g/mol
Synonyms	5-(tert-Butyldimethylsilyl)-1-methyl-1H-1,2,4-triazole; 1-Methyl-5-[(1,1-dimethylethyl)dimethylsilyl]-1H-1,2,4-triazole; 1-Methyl-5-(tert-butyldimethylsilyl)-1,2,4-triazole; tert-Butyldimethylsilyl 1-methyl-1,2,4-triazol-5-yl ether; TBDMS-1-methyl-1,2,4-triazole
EINECS	Contact for details

Quality Control

Every batch of our 1H-1,2,4-Triazole,5-[(1,1-Dimethylethyl)dimethylsilyl]-1-methyl-(9Ci) undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (by HPLC or GC), identity confirmation (by IR, NMR, or MS), and impurity profiles. Our quality management system supports cGMP compliance for advanced intermediate production, ensuring traceability and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC/GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.