Description

1H,3H-Pyrrolo[1,2-C][1,3,2]Oxazaborole, Tetrahydro-1-(2-Methylpropyl)-3,3-Diphenyl-, (R)- is a specialized, chiral organoboron compound that serves as a high-value intermediate and catalyst in advanced synthetic chemistry. Its significance lies in its role as a key building block for the synthesis of complex molecules, particularly in the pharmaceutical sector where stereochemical control is paramount. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new active ingredients or optimize synthetic routes.

Application

• Asymmetric Synthesis Catalyst/Precursor: Utilized as a chiral catalyst or catalyst precursor in enantioselective reactions, such as reductions or additions, to produce single-enantiomer intermediates.
• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) requiring specific stereochemistry, particularly for central nervous system (CNS) or antiviral drugs.
• Agrochemical Research: Employed in the development of novel, chiral pesticides and herbicides where biological activity is enantiomer-specific.
• Ligand for Metal Complexes: Can be used to develop novel chiral ligands for transition metal catalysis, expanding the toolbox for asymmetric transformations.
• Material Science Research: Investigated as a monomer or additive for creating polymers with unique optical or electronic properties.
• Academic & Industrial R&D: Serves as a valuable reagent for methodological development in organic and organometallic chemistry within university and corporate research laboratories.

Basic Information

Product Name	1H,3H-Pyrrolo[1,2-C][1,3,2]Oxazaborole, Tetrahydro-1-(2-Methylpropyl)-3,3-Diphenyl-, (R)-
CAS No.	142072-56-8
Molecular Formula	C22H28BNO
Molecular Weight	333.28 g/mol
Synonyms	(R)-Tetrahydro-1-isobutyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole; (R)-1-(2-Methylpropyl)-3,3-diphenyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole; (R)-1-Isobutyl-3,3-diphenyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole; Corey's (R)-Isobutyl Oxazaborolidine Catalyst; (R)-α,α-Diphenyl-2-pyrrolidinemethanol N-Isobutylboronate; (R)-3,3-Diphenyl-1-isobutyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole; Chiral Oxazaborolidine Catalyst; (R)-CBS Catalyst derivative.
EINECS	Contact for details

Quality Control

Our production of this high-purity chiral compound adheres to strict quality management protocols. Each batch is characterized using advanced analytical techniques including chiral HPLC, NMR (1H, 13C, 11B), and mass spectrometry to confirm identity, enantiomeric excess (ee), and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (argon or nitrogen) for long-term storage or after opening the original container to maintain stability and purity. Ideal storage temperature is between 2°C and 8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.