Description

Ethyl 1-Boc-5-Oxo-Hexahydro-1H-Azepine-4-Carboxylate is a high-purity, protected amino acid derivative and a key chiral building block in advanced organic synthesis. This compound is essential for constructing complex molecular architectures with precise stereochemical control, offering significant value in the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of peptidomimetics and other bioactive heterocycles.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of complex drug candidates, particularly those containing azepane or modified amino acid motifs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing focused libraries to explore structure-activity relationships (SAR) in drug discovery programs.
• Peptidomimetic Development: Used to introduce constrained, non-natural amino acid units into peptide backbones to enhance metabolic stability and bioavailability.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of target molecules.
• Academic & Contract Research: A valuable reagent for methodology development and the synthesis of novel heterocyclic compounds in academic and CRO settings.

Basic Information

Product Name	Ethyl 1-Boc-5-Oxo-Hexahydro-1H-Azepine-4-Carboxylate
CAS No.	141642-82-2
Molecular Formula	C14H23NO5
Molecular Weight	285.34 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-5-oxoazepane-4-carboxylic acid ethyl ester; Ethyl 1-(tert-butoxycarbonyl)-5-oxoazepane-4-carboxylate; 4-Carbethoxy-1-Boc-5-oxoazepane; 1-Boc-5-oxoazepane-4-carboxylic acid ethyl ester; 4-Ethoxycarbonyl-1-Boc-5-oxoazepane; Azepine-4-carboxylic acid, 1,2,3,4,5,6-hexahydro-5-oxo-1-[(1,1-dimethylethoxy)carbonyl]-, ethyl ester; BOC-Aze(O)-OEt
EINECS	Contact for details

Quality Control

Our Ethyl 1-Boc-5-Oxo-Hexahydro-1H-Azepine-4-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformity to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.