Description

N(Alpha)-(5-Deaza-5,6,7,8-Tetrahydropteroyl)Ornithine is a specialized folate analog and enzyme inhibitor of significant interest in biochemical research and pharmaceutical development. This compound matters for its role as a potent and specific inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folate metabolism and nucleic acid synthesis. It is primarily needed by research institutions and pharmaceutical companies engaged in cancer research, antimicrobial drug discovery, and the study of metabolic pathways.

Application

• Biochemical Research: Used as a specific inhibitor of dihydrofolate reductase (DHFR) in enzymatic studies and metabolic pathway analysis.
• Anticancer Research: Investigated for its potential to inhibit cell proliferation by disrupting folate metabolism in various cancer cell lines.
• Antimicrobial Agent Development: Serves as a lead compound or reference standard in the discovery of novel antibacterial and antiparasitic agents that target folate synthesis.
• Enzyme Kinetics & Mechanism Studies: Employed to study the binding affinity, kinetics, and inhibition mechanisms of DHFR enzymes from different sources.
• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical R&D.
• Academic Research: A key tool compound for universities and research institutes focusing on enzymology, medicinal chemistry, and molecular biology.

Basic Information

Product Name	N(Alpha)-(5-Deaza-5,6,7,8-Tetrahydropteroyl)Ornithine
CAS No.	141397-59-3
Molecular Formula	C20H27N7O5
Molecular Weight	445.47 g/mol
Synonyms	5-Deaza-5,6,7,8-tetrahydropteroylornithine; 5-Deaza-THP-Ornithine; NSC 654112; N(α)-(5-Deaza-5,6,7,8-tetrahydropteroyl)-L-ornithine; L-Ornithine, N-[4-[[(2-amino-5,6,7,8-tetrahydro-5-deaza-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-; DHFR Inhibitor (5-Deaza series); Folate Analog Inhibitor
EINECS	Contact for details

Quality Control

Our N(Alpha)-(5-Deaza-5,6,7,8-Tetrahydropteroyl)Ornithine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.