Description

Pyridine, 2-(3-Fluoro-3H-Diazirin-3-Yl)- (9Ci) is a specialized heterocyclic compound featuring a pyridine ring substituted with a photoactivatable 3-fluoro-3H-diazirinyl group. This compound is a critical reagent in advanced chemical biology and pharmaceutical research, serving as a versatile photoaffinity labeling agent for probing biomolecular interactions. It is primarily utilized by research scientists and process development chemists in the life sciences sector. The unique diazirine moiety allows for covalent crosslinking upon UV irradiation, enabling the study of protein-ligand binding sites and complex biological pathways.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalent capture and identification of transient or weak protein-ligand interactions in drug discovery.
• Chemical Proteomics: Used to create activity-based probes for profiling enzyme families and identifying drug targets within complex biological samples.
• Bioconjugation & Linker Chemistry: Serves as a photoreactive handle for the site-specific modification of biomolecules, peptides, and synthetic polymers.
• Material Science Functionalization: Employed to introduce photoreactive groups onto surfaces or nanomaterials for subsequent coupling with biological entities.
• Metabolic Pathway Analysis: Incorporated into probe molecules to trace and tag metabolites or biomolecules within living systems.
• Structural Biology Studies: Aids in mapping binding pockets and elucidating three-dimensional structures of macromolecular complexes.

Basic Information

Product Name	Pyridine, 2-(3-Fluoro-3H-Diazirin-3-Yl)- (9Ci)
CAS No.	141342-09-8
Molecular Formula	C7H5FN3
Molecular Weight	150.14 g/mol
Synonyms	2-(3-Fluoro-3H-diazirin-3-yl)pyridine; 3-(Pyridin-2-yl)-3H-diazirine-3-fluoride; 3-Fluoro-3-(2-pyridyl)diazirine; 2-(3-Fluorodiazirin-3-yl)pyridine; Photoaffinity Labeling Reagent; PAL Probe Precursor; Diazirine-Pyridine Conjugate; Aryl Diazirine Derivative
EINECS	Contact for details

Quality Control

Our production of Pyridine, 2-(3-Fluoro-3H-Diazirin-3-Yl)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm structural identity and high purity. Certificates of Analysis (COA) detailing all specification parameters are provided with every shipment. We support compliance with research and development standards under controlled environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at recommended temperatures between -20°C to -10°C for long-term stability, or at 2-8°C for short-term use. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., argon or nitrogen) when not in use and handled in low-light conditions to prevent decomposition.

Specification

Item	Specification
Appearance	Light yellow to yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.