Description

4-Chloro-2-Fluorobenzenesulfonyl Chloride is a high-purity, multi-functional sulfonyl chloride derivative serving as a critical building block in advanced organic synthesis. Its value lies in its dual reactive sites, enabling the efficient introduction of the 4-chloro-2-fluorobenzenesulfonyl moiety into target molecules, which is essential for modulating biological activity and physical properties. This intermediate is particularly vital for pharmaceutical, agrochemical, and specialty chemical researchers and manufacturers developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the sulfonyl group enhances efficacy and selectivity.
• Material Science: Employed in the production of specialty polymers, dyes, and liquid crystals to impart specific functional characteristics.
• Chemical Research & Development: Serves as a versatile reagent for constructing complex molecular architectures in medicinal and process chemistry.
• Custom Synthesis: A fundamental starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds.

Basic Information

Product Name	4-Chloro-2-Fluorobenzenesulfonyl Chloride
CAS No.	141337-26-0
Molecular Formula	C6H3Cl2FO2S
Molecular Weight	229.05 g/mol
Synonyms	1-Chloro-4-fluoro-2-sulfonylchloride-benzene; 2-Fluoro-4-chlorobenzenesulfonyl chloride; 4-Chloro-2-fluorobenzene-1-sulfonyl chloride; Benzenesulfonyl chloride, 4-chloro-2-fluoro-; 4-Chloro-2-fluorophenylsulfonyl chloride; 2-Fluoro-4-chlorophenylsulfonyl chloride; 4-Chloro-2-fluoro-1-benzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2-Fluorobenzenesulfonyl Chloride is manufactured under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment, and we support compliance with relevant regulatory frameworks for our global customer base.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.