Description

(1S,2R)-2-Fluorocyclopropan-1-Amine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. Its value lies in its unique fluorinated cyclopropane scaffold, which is critical for modulating the biological activity, metabolic stability, and physicochemical properties of advanced drug candidates. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of small molecule drugs, especially in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the synthesis of novel pesticides and herbicides, where the fluorocyclopropane moiety can enhance biological activity and environmental stability.
• Methodology Development: Serves as a valuable substrate in academic and industrial research for developing new asymmetric synthesis and fluorination methodologies.
• Peptidomimetics & Bioisosteres: The fluorinated cyclopropylamine group acts as a rigid, polar bioisostere for peptide bonds or other functional groups in drug design.
• Ligand & Catalyst Synthesis: Employed in the preparation of chiral ligands and organocatalysts for enantioselective transformations.

Basic Information

Product Name	(1S,2R)-2-Fluorocyclopropan-1-Amine Hydrochloride
CAS No.	141042-20-8
Molecular Formula	C3H7ClFN
Molecular Weight	111.55 g/mol
Synonyms	(1S,2R)-2-Fluorocyclopropanamine Hydrochloride; (1S,2R)-2-Fluorocyclopropylamine HCl; trans-2-Fluorocyclopropan-1-amine Hydrochloride; (1S,2R)-1-Amino-2-fluorocyclopropane Hydrochloride; 2-Fluorocyclopropan-1-amine Hydrochloride (trans-); FCAP-HCl; (1S,2R)-2-F-CPA HCl
EINECS	Contact for details

Quality Control

Our (1S,2R)-2-Fluorocyclopropan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR, and mass spectrometry for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) with full specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.