Description

(S)-5-(3-(2-Hydroxyethylthio)-5-Methoxy-4-Propoxyphenyl)Dihydrofuran-2(3H)-One is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters because it provides a critical, stereochemically defined building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high specificity. Pharmaceutical R&D teams and fine chemical manufacturers need this material for constructing complex molecular architectures where the (S)-configuration is essential for biological activity and process efficiency.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to introduce the (S)-configured dihydrofuranone moiety into target molecules.
• Process Chemistry Development: Serves as a starting material or advanced intermediate for scaling up API manufacturing processes under GMP conditions.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Custom Synthesis & Contract Manufacturing: A critical component for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical synthesis services.

Basic Information

Product Name	(S)-5-(3-(2-Hydroxyethylthio)-5-Methoxy-4-Propoxyphenyl)Dihydrofuran-2(3H)-One
CAS No.	140705-18-6
Molecular Formula	C₁₆H₂₂O₅S
Molecular Weight	326.41 g/mol
Synonyms	(S)-5-[3-(2-Hydroxyethylsulfanyl)-5-methoxy-4-propoxyphenyl]dihydrofuran-2-one; (S)-5-(3-(2-Hydroxyethylthio)-5-methoxy-4-propoxyphenyl)tetrahydrofuran-2-one; (S)-Dihydrofuranone derivative CAS 140705-18-6; (S)-enantiomer of the dihydrofuranone intermediate; (S)-configured aryl dihydrofuranone; Light-sensitive chiral intermediate 140705-18-6
EINECS	Contact for details

Quality Control

Our (S)-5-(3-(2-Hydroxyethylthio)-5-Methoxy-4-Propoxyphenyl)Dihydrofuran-2(3H)-One is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. Each lot undergoes comprehensive analytical characterization including chiral purity verification by HPLC. Certificates of Analysis (COA) detailing identity, assay, chiral purity, and impurity profiles are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.