Description

16-Hydroxytriptolide is a bioactive diterpenoid epoxide and a key derivative of the natural product triptolide. This compound is of significant interest in pharmaceutical research and development due to its potent biological activity profile. It serves as a critical intermediate and reference standard for scientists in the life sciences sector, particularly those focused on immunology, oncology, and anti-inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel therapeutic agents targeting autoimmune diseases and cancer.
• Biochemical Research: Used as a reference standard and active agent in in vitro and in vivo studies to investigate mechanisms of action related to NF-κB inhibition and apoptosis induction.
• Reference Material: Essential for analytical method development and validation in quality control laboratories for triptolide-related compounds.
• Drug Discovery & Development: A valuable compound for high-throughput screening and structure-activity relationship (SAR) studies to develop new immunomodulatory drugs.

Basic Information

Product Name	16-Hydroxytriptolide
CAS No.	139713-80-7
Molecular Formula	C20H24O7
Molecular Weight	376.40 g/mol
Synonyms	(5R,5aR,6R,6aS,7S,8S,9S,9aR,9bS)-6-(Hydroxymethyl)-9b-hydroxy-5a,6,6a,7,8,9,9a,9b-octahydro-5-(3-hydroxypropyl)-7,9a-dimethylnaphtho[1,2-c]furan-1(3H)-one; 16-Hydroxy-triptolide; Triptolide, 16-hydroxy-; 16-Hydroxy Tripterine
EINECS	Contact for details

Quality Control

Our 16-Hydroxytriptolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.