Description

(2-[2-(2-Hydroxy-Ethoxy)-Ethoxy]-Ethyl)-Carbamic Acid tert-Butyl Ester is a specialized protected amine derivative featuring a hydrophilic triethylene glycol spacer. This compound matters as a versatile building block for introducing amine functionality with enhanced solubility and controlled reactivity into complex molecular architectures. It is primarily needed by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for applications such as peptide synthesis, polymer modification, and the development of drug delivery systems.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs) and prodrugs requiring a solubilizing linker.
• Peptide & Protein Modification: Used to introduce a protected amine handle onto peptides, proteins, or antibodies for subsequent conjugation (PEGylation, labeling).
• Polymer & Dendrimer Synthesis: Serves as a functional monomer or end-group for creating amine-functionalized polymers, hydrogels, and dendritic structures.
• Bioconjugation Chemistry: Facilitates the attachment of drugs, dyes, or other molecules to biological entities via its cleavable tert-butyloxycarbonyl (Boc) protecting group.
• Linker for Solid-Phase Synthesis: Employed in combinatorial chemistry and solid-phase peptide synthesis (SPPS) as a soluble, protected linker.
• Surface Functionalization: Used to coat nanoparticles, quantum dots, or other material surfaces with a reactive amine layer for further derivatization.

Basic Information

Product Name	(2-[2-(2-Hydroxy-Ethoxy)-Ethoxy]-Ethyl)-Carbamic Acid tert-Butyl Ester
CAS No.	139115-92-7
Molecular Formula	C13H27NO6
Molecular Weight	293.36 g/mol
Synonyms	2,2'-Ethylenedioxydiethanol, 1-[2-[2-(Boc-amino)ethoxy]ethoxy]ethyl ether; Boc-NH-PEG3-alcohol; Boc-Amine-PEG3-OH; tert-Butyl N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]carbamate; 3-(Boc-amino)-1,5,9-trioxa-12-azadodecan-12-ol; Amino-PEG3-alcohol Boc-protected; Boc-8-amino-3,6-dioxaoctan-1-ol
EINECS	Contact for details

Quality Control

Our (2-[2-(2-Hydroxy-Ethoxy)-Ethoxy]-Ethyl)-Carbamic Acid tert-Butyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.