Description

Isomurralonginol Acetate is a bioactive sesquiterpene lactone derivative isolated from Murra species (e.g., Murraya paniculata) and structurally characterized by an α,β-unsaturated γ-lactone moiety with an acetate ester at the C-11 position. It serves as a high-value reference standard and pharmacological probe for anti-inflammatory, antitumor, and antiviral mechanism studies due to its selective NF-κB and STAT3 pathway modulation. This compound is primarily utilized by pharmaceutical R&D laboratories, natural product research institutes, and contract development and manufacturing organizations (CDMOs) engaged in botanical drug discovery and preclinical candidate optimization. Isomurralonginol Acetate CAS NO 139115-59-6 is supplied under strict quality-controlled conditions to ensure batch-to-batch reproducibility and structural integrity.

Application

• Reference standard for HPLC and LC-MS quantitative analysis of Murraya-derived botanical extracts
• Lead compound in structure–activity relationship (SAR) studies targeting sesquiterpene lactone-based anticancer agents
• In vitro pharmacological tool for evaluating inhibition of pro-inflammatory cytokine production (e.g., TNF-α, IL-6) in macrophage models
• Chemical probe for studying IκB kinase (IKK) and JAK/STAT signaling crosstalk in oncology research
• Starting material for semi-synthetic derivatization to improve solubility, metabolic stability, or target selectivity
• Calibration standard in regulatory submissions for herbal medicinal product characterization (EMA/HMPC & FDA Botanical Guidance compliant)
• Quality control marker for standardized Murraya paniculata leaf extract formulations in nutraceutical development

Basic Information

Product Name	Isomurralonginol Acetate
CAS No.	139115-59-6
Molecular Formula	C20H24O6
Molecular Weight	360.40 g/mol
Synonyms	Isomurralonginol acetate; 11-O-Acetylisomurralonginol; (1R,4aR,5S,7aS,8R,9R)-1,5-Dihydroxy-8-(3-methylbut-2-enoyl)-2-oxo-1,2,4a,5,6,7,7a,8,9,9a-decahydroazuleno[4,5-b]furan-9-yl acetate; Isomurralonginol 11-acetate; NSC 726152; Murralonginol acetate isomer; 11-Acetoxy-1,5-dihydroxymurralonginol; Acetyl-isomurralonginol
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are verified for identity (IR, HPLC retention time match, and NMR fingerprinting), assay purity (≥98.5% by HPLC-UV), residual solvents (meets ICH Q3C Class 3 limits), and heavy metals (≤10 ppm total). Testing follows validated methods aligned with USP & EP general chapters for organic reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (nitrogen or argon) to prevent oxidation and hydrolysis. Keep away from moisture and strong oxidizing agents. Maintain in a well-ventilated area free from incompatible materials such as strong alkalis and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Odor	Characteristic mild odor
Identification (IR)	Conforms to reference spectrum (peaks at 1765 cm⁻¹, 1670 cm⁻¹, 1610 cm⁻¹)
Identification (HPLC)	Retention time matches certified reference standard (±0.2 min)
Assay (HPLC-UV)	98.5–101.0%
Related Substances (HPLC)	Single impurity ≤0.3%; Total impurities ≤0.5%
Residue on Ignition	≤0.1%
Water (Karl Fischer)	≤0.5%
Heavy Metals	≤10 ppm
Sulfated Ash	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.