Description

2,3-Bis[[(E)-Octadec-9-Enoyl]Oxy]Propoxy-[2-[(2,2,2-Trifluoroacetyl)Amino]Ethoxy]Phosphinic Acid is a sophisticated synthetic phospholipid derivative, engineered for advanced research and development applications. This compound is valued for its unique molecular architecture, which combines a phosphinic acid core with oleoyl (C18:1) chains and a trifluoroacetyl-protected aminoethoxy moiety, offering specific reactivity and amphiphilic properties. It is primarily utilized by researchers and product developers in the pharmaceutical, biotechnology, and specialty chemical sectors for applications such as novel drug delivery system formulation, membrane biophysics studies, and as a key synthetic intermediate.

Application

• Lipid Nanoparticle (LNP) & Liposome Formulation: Serves as a functionalized phospholipid component for constructing targeted or stimuli-responsive drug delivery vehicles.
• Synthetic Intermediate: Used in the synthesis of more complex, headgroup-modified phospholipids for specialized research applications.
• Membrane Protein Research: Acts as a component in model membrane systems (e.g., liposomes, nanodiscs) to study protein-lipid interactions.
• Bioconjugation & Probe Development: The reactive phosphinic acid and protected amine groups provide handles for conjugation with drugs, dyes, or targeting ligands.
• Surface Chemistry & Material Science: Can be used to create functionalized lipid monolayers or bilayers on surfaces for sensor development.
• Biomimetic Chemistry: Employed in the construction of artificial cellular membranes and protocell models.

Basic Information

Product Name	2,3-Bis[[(E)-Octadec-9-Enoyl]Oxy]Propoxy-[2-[(2,2,2-Trifluoroacetyl)Amino]Ethoxy]Phosphinic Acid
CAS No.	138898-69-8
Molecular Formula	C45H79F3NO9P
Molecular Weight	866.08 g/mol
Synonyms	1,2-Dioleoyl-sn-glycero-3-phospho(TFA-aminoethoxy); 2,3-Bis(oleoyloxy)propyl (2-((2,2,2-trifluoroacetyl)amino)ethoxy)phosphinate; TFA-Amino-PE Precursor; Phosphoethanolamine-N-TFA, dioleoyl derivative; 1,2-Di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-(2,2,2-trifluoroacetyl)ethanolamine; (2,2,2-Trifluoroacetamidoethyl) DOP Phosphinate; N-(Trifluoroacetyl)-DOPE analog
EINECS	Contact for details

Quality Control

Our production of 2,3-Bis[[(E)-Octadec-9-Enoyl]Oxy]Propoxy-[2-[(2,2,2-Trifluoroacetyl)Amino]Ethoxy]Phosphinic Acid adheres to stringent internal quality standards to ensure batch-to-batch consistency and purity suitable for research applications. Identity and purity are confirmed via advanced analytical techniques including NMR and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing specific lot results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white waxy solid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.