Description

Butanedioic Acid, 1-(1,1-Dimethylethyl) 4-(2,5-Dioxo-1-Pyrrolidinyl) Ester is a specialized chemical intermediate featuring a succinate core protected by a tert-butyl group and activated by a 2,5-dioxopyrrolidinyl (succinimidyl) ester. This molecular architecture makes it a valuable reagent for the controlled synthesis of amides and esters, particularly in peptide coupling and polymer modification. It is primarily sought by research and development teams in the pharmaceutical and advanced materials sectors for constructing complex molecules with high precision.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, leveraging its activated ester group for efficient amide bond formation under mild conditions.
• Peptide Synthesis: Serves as a coupling reagent or protected building block in solid-phase and solution-phase peptide chemistry.
• Polymer Functionalization: Employed to introduce succinimidyl ester groups onto polymer backbones, enabling subsequent conjugation with amines for creating functionalized materials.
• Bioconjugation: Facilitates the labeling and cross-linking of biomolecules (e.g., proteins, antibodies) with other molecules or surfaces in diagnostic and therapeutic research.
• Organic Synthesis Reagent: Acts as a versatile tert-butyl-protected succinylating agent in multi-step organic syntheses for fine chemicals.
• Cross-linking Agent: Used in the development of hydrogels, coatings, and other cross-linked polymeric networks where controlled reactivity is required.

Basic Information

Product Name	Butanedioic Acid, 1-(1,1-Dimethylethyl) 4-(2,5-Dioxo-1-Pyrrolidinyl) Ester
CAS No.	138833-93-9
Molecular Formula	C12H17NO5
Molecular Weight	255.27 g/mol
Synonyms	tert-Butyl 4-(2,5-dioxo-1-pyrrolidinyl)-4-oxobutanoate; N-Succinimidyl tert-Butyl Succinate; Succinic Acid Mono-tert-butyl Ester N-Hydroxysuccinimide Ester; N-Hydroxysuccinimidyl tert-Butyl Succinate; tert-Butyl Succinimidyl Succinate; 4-(2,5-Dioxo-1-pyrrolidinyl)-4-oxobutanoic Acid 1,1-Dimethylethyl Ester; N-(tert-Butoxycarbonylpropionyloxy)succinimide; STB Succinate
EINECS	Contact for details

Quality Control

Our production of Butanedioic Acid, 1-(1,1-Dimethylethyl) 4-(2,5-Dioxo-1-Pyrrolidinyl) Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets exacting standards for research and industrial use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.