Description

(1S,2S)-3,3-Dimethoxy-1,2-Cyclobutanedimethanol is a high-purity chiral building block and synthetic intermediate of significant value in advanced organic synthesis. This compound matters for its role as a key precursor in the production of complex, stereochemically defined molecules, particularly in the pharmaceutical sector. It is primarily needed by research chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals where precise stereochemistry is critical for biological activity.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), especially those requiring a rigid, functionalized cyclobutane core.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where specific stereochemistry influences efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a backbone for creating chiral ligands and organocatalysts used in asymmetric synthesis to control reaction stereoselectivity.
• Material Science Research: Potential monomer or cross-linking agent in the development of novel polymers with specific mechanical or optical properties derived from its strained ring structure.
• Academic and Industrial R&D: A valuable tool for methodological studies in organic chemistry, enabling new routes to complex, stereodefined molecular architectures.

Basic Information

Product Name	(1S,2S)-3,3-Dimethoxy-1,2-Cyclobutanedimethanol
CAS No.	138736-92-2
Molecular Formula	C8H16O4
Molecular Weight	176.21 g/mol
Synonyms	(1S,2S)-1,2-Bis(hydroxymethyl)-3,3-dimethoxycyclobutane; (1S,2S)-3,3-Dimethoxycyclobutane-1,2-dimethanol; cis-3,3-Dimethoxy-1,2-cyclobutanedimethanol; (1S,2S)-rel-3,3-Dimethoxy-1,2-cyclobutanedimethanol; (1S-cis)-3,3-Dimethoxy-1,2-cyclobutanedimethanol; Cyclobutanedimethanol, 3,3-dimethoxy-, (1S,2S)-
EINECS	Contact for details

Quality Control

Our (1S,2S)-3,3-Dimethoxy-1,2-Cyclobutanedimethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical assay, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation, especially after the original container has been opened. Recommended storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.