Description

(2E)-3-(Dimethylamino)-1-(4-Fluorophenyl)Prop-2-En-1-One is a specialized fluorinated enaminone building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring a reactive α,β-unsaturated ketone core linked to a dimethylamino group and a fluorinated aromatic ring, makes it a versatile precursor for constructing complex heterocyclic systems. This high-purity intermediate is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, where the introduction of fluorine atoms is a key strategy to modulate biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom enhances lipophilicity and environmental stability of the active molecule.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and advanced organic materials with tailored optical or electronic properties.
• Chemical Synthesis Building Block: Employed in Michael addition reactions, cyclocondensations, and as a substrate for further functionalization to create libraries of diverse chemical entities for screening.
• Academic & Contract Research: Essential for methodological studies in organic chemistry, particularly in research focused on fluorine chemistry and the development of new catalytic asymmetric transformations.

Basic Information

Item	Details
Product Name	(2E)-3-(Dimethylamino)-1-(4-Fluorophenyl)Prop-2-En-1-One
CAS No.	138716-20-8
Molecular Formula	C11H12FNO
Molecular Weight	193.22 g/mol
Synonyms	1-(4-Fluorophenyl)-3-(dimethylamino)-2-propen-1-one; (E)-3-(Dimethylamino)-1-(4-fluorophenyl)-2-propen-1-one; 4-Fluorochalcone N,N-dimethylhydrazone; 3-Dimethylamino-1-(4-fluorophenyl)-2-propen-1-one; (E)-3-(Dimethylamino)-1-(p-fluorophenyl)prop-2-en-1-one; p-Fluoro-β-dimethylaminopropiophenone; Enaminone F1
EINECS	Contact for details

Quality Control

Every batch of (2E)-3-(Dimethylamino)-1-(4-Fluorophenyl)Prop-2-En-1-One is manufactured under strict quality management systems. We guarantee high chemical purity and consistent isomeric composition (E-isomer) through rigorous analytical controls including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure traceability and compliance with your research or production protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider an inert atmosphere to preserve optimal purity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0% (Area %)
Isomeric Purity (E-isomer)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.