Description

20-Oxo-12,20-Dideoxyphorbol 13-Phenylacetate is a high-purity, semi-synthetic derivative of the phorbol diterpene family, known for its specific biological activity profile. This compound is of significant interest for advanced research in cell signaling pathways and as a critical reference standard in analytical chemistry. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in the study of protein kinase C (PKC) modulation and related therapeutic areas.

Application

• Biomedical Research: A key tool compound for studying protein kinase C (PKC) activation, signal transduction, and cellular differentiation mechanisms.
• Pharmacology & Toxicology: Used in in vitro and in vivo studies to investigate the biological effects of phorbol esters and develop potential therapeutic or diagnostic agents.
• Analytical Reference Standard: Serves as a certified reference material (CRM) for the identification, purity assessment, and quantification of related compounds via HPLC, LC-MS, or NMR in quality control laboratories.
• Chemical Synthesis Intermediate: Acts as a sophisticated building block for the semi-synthesis of novel analogs with modified biological properties for structure-activity relationship (SAR) studies.
• Cell Biology Studies: Employed in experiments to induce specific cellular responses, such as tumor promotion studies in controlled research settings to understand carcinogenesis.

Basic Information

Product Name	20-Oxo-12,20-Dideoxyphorbol 13-Phenylacetate
CAS No.	138574-84-2
Molecular Formula	C30H36O7
Molecular Weight	508.61 g/mol
Synonyms	12-Deoxyphorbol 13-phenylacetate 20-acetate; 20-Oxo-12-deoxyphorbol 13-phenylacetate; 12,20-Dideoxy-20-oxophorbol 13-phenylacetate; NSC 401005; Phorbol 13-phenylacetate derivative; 13-O-Phenylacetyl-20-oxo-12,20-dideoxyphorbol; 20-Oxo-12,20-dideoxyphorbol-13-phenylacetate
EINECS	Contact for details

Quality Control

Our 20-Oxo-12,20-Dideoxyphorbol 13-Phenylacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and determination of residual solvents to ensure it meets the stringent requirements for research and reference standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.