Description

Cyclobutaneacetonitrile, 3-Acetyl-2,2-Dimethyl-, (1R-Cis)- (9Ci) is a high-purity, chiral organic intermediate of significant interest in advanced chemical synthesis. This compound matters for its role as a sophisticated building block, enabling the construction of complex molecular architectures with precise stereochemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce the cyclobutane moiety with defined stereochemistry.
• Agrochemical Research: Serves as a precursor in the synthesis of advanced, biologically active molecules for crop protection.
• Material Science: Investigated as a monomer or cross-linking agent for creating polymers with unique thermal and mechanical properties.
• Academic & Process Chemistry: Used in methodological studies and scale-up process development for complex organic molecules.
• Fragrance & Flavor Chemistry: Potential intermediate for synthesizing novel musk or woody aroma chemicals due to its complex, constrained ring structure.

Basic Information

Product Name	Cyclobutaneacetonitrile, 3-Acetyl-2,2-Dimethyl-, (1R-Cis)- (9Ci)
CAS No.	138512-75-1
Molecular Formula	C10H15NO
Molecular Weight	165.23 g/mol
Synonyms	(1R,3S)-3-Acetyl-2,2-dimethylcyclobutaneacetonitrile; (1R-cis)-3-Acetyl-2,2-dimethylcyclobutanecetonitrile; 2,2-Dimethyl-3-acetyl-(1R,3S)-cyclobutanecetonitrile; 3-Acetyl-2,2-dimethyl-(1R-cis)-cyclobutanecetonitrile; (1R,3S)-2,2-Dimethyl-3-(2-oxoethyl)cyclobutanecarbonitrile; cis-3-Acetyl-2,2-dimethylcyclobutaneacetonitrile
EINECS	Contact for details

Quality Control

Our Cyclobutaneacetonitrile, 3-Acetyl-2,2-Dimethyl-, (1R-Cis)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.