Description

4-Aminomethylphenylboronic Acid, Pinacol Ester, Hcl is a protected boronic acid derivative that serves as a crucial synthetic intermediate in modern organic chemistry. Its value lies in the dual functionality of the protected boronate group and the primary amine, enabling its use in cross-coupling reactions and subsequent derivatization under mild conditions. This compound is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures, particularly in Suzuki-Miyaura coupling and bioconjugation strategies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring aryl-boronate intermediates.
• Bioconjugation & Probe Development: The amine functionality allows for attachment to biomolecules (proteins, peptides, antibodies) for creating diagnostic probes or targeted drug delivery systems.
• Materials Science: Serves as a monomer or functionalization agent in the synthesis of advanced polymers, OLED materials, and covalent organic frameworks (COFs).
• Chemical Biology Research: Utilized as a tool compound for studying biological processes and developing enzyme inhibitors.
• Library Synthesis: Enables high-throughput parallel synthesis for medicinal chemistry and hit-to-lead optimization programs in drug discovery.

Basic Information

Product Name	4-Aminomethylphenylboronic Acid, Pinacol Ester, Hcl
CAS No.	138500-88-6
Molecular Formula	C13H21BClNO2
Molecular Weight	269.57 g/mol
Synonyms	Benzenemethanamine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, hydrochloride (1:1); 4-(Aminomethyl)phenylboronic acid pinacol ester hydrochloride; (4-(Aminomethyl)phenyl)boronic acid pinacol ester hydrochloride; 4-(Boc-amino)phenylboronic acid pinacol ester HCl (common error/related); 4-(Aminomethyl)benzeneboronic acid pinacol ester hydrochloride; 2-(4-(Aminomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Aminomethylphenylboronic Acid, Pinacol Ester, Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for water content, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.