Description

4-(Bromomethyl)Benzeneboronic Acid Pinacol Ester is a versatile and high-purity organoboron building block essential for modern synthetic chemistry. This compound matters because it combines a reactive benzylic bromide handle with a protected boronic acid group, enabling sequential cross-coupling and functionalization reactions in a single molecule. It is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific biphenyl or substituted aromatic structures.
• Ligand and Catalyst Development: Serves as a precursor for creating sophisticated ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) with tailored electronic properties.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and bioconjugates for proteomics and diagnostic assay development.
• Sequential Functionalization: Enables orthogonal synthesis strategies where the boronic ester and bromomethyl groups are modified in a specific order to create diverse compound libraries.

Basic Information

Product Name	4-(Bromomethyl)Benzeneboronic Acid Pinacol Ester
CAS No.	138500-85-3
Molecular Formula	C₁₃H₁₈BBrO₂
Molecular Weight	297.00 g/mol
Synonyms	[4-(Bromomethyl)phenyl]boronic acid pinacol ester; 1-Bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylbenzene; 4-(Bromomethyl)phenylboronic acid pinacol ester; 2-[4-(Bromomethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol [4-(Bromomethyl)phenyl]boronate; (4-(Bromomethyl)phenyl)boronic acid pinacol ester; 4-Bromomethylbenzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-(Bromomethyl)Benzeneboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting industry standards. Certificates of Analysis (COA) with full traceability are provided to guarantee reliable performance in your critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the original container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.