Description

1-Cyclobutene-1-Carboxylicacid,3-Ethylidene-4-Methyl-,Methylester,[R-(Z)]- is a high-purity, stereochemically defined cyclobutene derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique fused ring structure and defined stereochemistry make it an invaluable intermediate for constructing complex molecular architectures with high precision. This compound is primarily sought after by research institutions and pharmaceutical development teams working on novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, particularly in constructing constrained ring systems.
• Agrochemical Synthesis: Used in the creation of advanced, stereoselective pesticides and herbicides with targeted activity.
• Material Science Research: Serves as a precursor for developing specialized polymers and liquid crystals with unique optical or mechanical properties.
• Asymmetric Catalysis: Employed as a ligand precursor or a test substrate in the development of new asymmetric catalytic processes.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic chemistry, including cycloaddition reactions and ring-opening polymerizations.
• Flavor & Fragrance Industry: Potential intermediate for synthesizing complex, naturally-derived odorant molecules.

Basic Information

Product Name	1-Cyclobutene-1-Carboxylicacid,3-Ethylidene-4-Methyl-,Methylester,[R-(Z)]-
CAS No.	138337-29-8
Molecular Formula	C9H12O2
Molecular Weight	152.19 g/mol
Synonyms	(R,Z)-Methyl 3-ethylidene-4-methyl-1-cyclobutene-1-carboxylate; Methyl (1R,3Z)-3-ethylidene-4-methyl-1-cyclobutene-1-carboxylate; (Z)-Methyl 3-ethylidene-4-methyl-1-cyclobutene-1-carboxylate (R)-; 1-Cyclobutene-1-carboxylic acid, 3-ethylidene-4-methyl-, methyl ester, (R,Z)-; 138337-29-8; (R)-(Z)-3-Ethylidene-4-methyl-1-cyclobutene-1-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of 1-Cyclobutene-1-Carboxylicacid,3-Ethylidene-4-Methyl-,Methylester,[R-(Z)]- is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure the identity, purity, and stereochemical integrity of the product meet the exacting standards required for research and development. A Certificate of Analysis (COA) detailing chiral purity (enantiomeric excess), chemical purity by HPLC, and full spectroscopic data (NMR, IR, MS) is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound should be handled under an inert atmosphere for long-term storage to maintain optimal stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.