Description

1-Cyclobutene-1-Carboxylicacid,3-Ethylidene-4-Methyl-,Methylester,[R-(E)]- is a high-purity, stereochemically defined cyclobutene derivative. This compound serves as a versatile and valuable chiral building block in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily needed by pharmaceutical R&D and fine chemical industries for the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates with complex cyclic structures.
• Asymmetric Synthesis: Used as a precursor in catalytic asymmetric reactions to introduce the cyclobutene moiety with high enantiomeric purity.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, or plant growth regulators that require specific stereochemistry.
• Material Science: Potential monomer or cross-linking agent for the development of specialized polymers with unique thermal or mechanical properties.
• Academic & Industrial R&D: Serves as a model compound or starting material in methodological studies and process chemistry optimization within organic chemistry laboratories.
• Fragrance & Flavor Chemistry: Can be utilized in the synthesis of complex odorants or flavor molecules where the strained ring system contributes to the sensory profile.

Basic Information

Product Name	1-Cyclobutene-1-Carboxylicacid,3-Ethylidene-4-Methyl-,Methylester,[R-(E)]-
CAS No.	138337-28-7
Molecular Formula	C9H12O2
Molecular Weight	152.19 g/mol
Synonyms	(R,E)-Methyl 3-ethylidene-4-methyl-1-cyclobutene-1-carboxylate; Methyl (1R,3E)-3-ethylidene-4-methyl-1-cyclobutene-1-carboxylate; (R)-(E)-3-Ethylidene-4-methyl-1-cyclobutene-1-carboxylic acid methyl ester; (1R,3E)-3-Ethylidene-4-methylcyclobut-1-ene-1-carboxylic acid methyl ester; 1-Cyclobutene-1-carboxylic acid, 3-ethylidene-4-methyl-, methyl ester, (R-(E))-; (R,E)-3-Ethylidene-4-methylcyclobut-1-ene-1-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing specific parameters are available upon request. We adhere to a cGMP-compliant quality management system for traceability and consistency, suitable for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.